Symbol
Name
ID

Stk11
serine/threonine kinase 11
MGI:1341870

Phenotype annotations related to endocrine/exocrine glands

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Exocrine pancreatic insufficiency	Neoplasm of the pancreas	Pancreatic adenocarcinoma	Precocious puberty with Sertoli cell tumor
Disease(s) Associated with STK11	Diabetes mellitus	Exocrine pancreatic insufficiency	Neoplasm of the pancreas	Pancreatic adenocarcinoma	Precocious puberty with Sertoli cell tumor
pancreatic cancer
Peutz-Jeghers syndrome

Mouse Phenotypes

increased pancreas apoptosis

increased Sertoli cell proliferation

abnormal exocrine pancreas morphology

abnormal pancreatic acinus morphology

abnormal pancreatic acinar cell morphology

endocrine/exocrine gland phenotype

abnormal pancreatic islet morphology

decreased pancreatic alpha cell number

decreased pancreatic beta cell number

decreased pancreatic delta cell number

small pancreatic islets

thymus hypoplasia

small pancreas

pancreas fibrosis

abnormal testis morphology

abnormal seminiferous tubule morphology

abnormal seminiferous tubule epithelium morphology

abnormal Sertoli cell morphology

decreased testis weight

small testis

pancreas inflammation

Availability

Mouse Genotype

Stk11^tm1.1Rdp/Stk11^tm1.1Rdp
Tg(Pdx1-cre)89.1Dam/0 (conditional)

Stk11^tm1.1Sjm/Stk11^tm1.1Sjm
Tg(Mx1-cre)1Cgn/0 (conditional)

Stk11^tm1Keis/Stk11^tm1Keis
Tg(Pomc1-cre)1Gsb/0 (conditional)

Amhr2^tm3(cre)Bhr/Amhr2⁺
Stk11^tm1Rdp/Stk11^tm1Rdp (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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